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Manchester has built on its strong scientific and academic heritage to become a global 21st century city of science and innovation. Productivity, the Greater Manchester Strategy 2013 notes, "will be driven by the next generation of advanced products that respond to changing global demand. The winners will be those who can create and produce the multi-purpose technology that makes those products possible. "In order to grasp the new opportunities identified by the research base, cities, institutions and businesses need to be open to innovative ideas and processes." Manchester's leading experience in urbanisation, agglomeration, and technological evolution puts it in a strong position to anticipate that growing demand and to adapt itself to supply into it. Science, technology, research and development are at the heart of Manchester's plans for growth. The Greater Manchester Strategy notes that "our growth strategy will focus on how our public, private and academic institutions can act collectively to translate our science and technology assets into additional economic output for Greater Manchester and the UK." Manchester has always been prepared to grasp change. It has never been locked into its history, its technologies and its traditional ways of working. The authors of the case studies in this booklet have identified that 21st century innovation works best when: > The necessary building blocks are in place > The right people are connected to each other > There is both openness to new ideas and a tolerance of risk and potential failure Global 21st century city of science and innovation 6 The University of Manchester Innovation Centre's Core Technology Faculty (CTF)