Issue link: https://htpgraphics.uberflip.com/i/1055210
SPIN-OUT AMPROLOGIX TO DEVELOP NEW ANTIBIOTICS TO HELP COMBAT ANTIMICROBIAL RESISTANCE IN PARTNERSHIP WITH INGENZA In September, Frontier IP, a specialist in commercialising university intellectual property, announced it has taken a 10 per cent stake in Amprologix Limited, a spin-out from the University of Plymouth. The company has been established to introduce new antibiotics, helping to tackle antimicrobial resistance, a major threat to human health globally. It will develop and commercialise the work of Dr Mathew Upton, Professor in Medical Microbiology at the University's School of Biomedical Sciences. The first product from the Company is expected to be a cream containing epidermicin, one of the new antibiotics being developed to combat infections caused by antibiotic-resistant bacteria. Epidermicin can rapidly kill harmful bacteria including MRSA (methicillin resistant Staphylococcus aureus), Streptococcus and Enterococcus at very low doses, even if they are resistant to other antibiotics. No new classes of antibiotics have been introduced into clinical use for the past 30 years, and the company is aiming to meet a growing need for new antibiotics as harmful microbes become increasingly drug resistant. It has already secured industry involvement through a partnership with world-leading biotechnology and synthetic biology company Ingenza. The new company is focused on four areas: > Developing epidermicin for commercial use > Discovering additional sources for new classes of antibiotics > Using Artificial Intelligence to improve antibiotic properties, working with Ingenza, IBM and the National Physical Laboratory > Developing efficient techniques to manufacture antibiotics at scale in partnership with Ingenza In a relevant infection model, a single dose of epidermicin was as effective as six doses of the current standard of care. The antibiotic was initially recovered from a skin bacterium named Staphylococcus epidermidis, but can now be produced in a microbe suitable for industrial scale-up, using synthetic biology methods developed by Ingenza. Professor Upton initially developed the patented technology working closely with UMI 3 Ltd at The University of Manchester, which now takes a 13 per cent stake in the new business. The World Health Organisation warned in February this year that "antibiotic resistance is one of the biggest threats to global health, food security, and development today".